Open architecture of archaea MCM and dsDNA complexes resolved using monodispersed streptavidin affinity CryoEM
Abstract The cryo-electron microscopy (cryoEM) method has folk rivet sweat enabled high-resolution structure determination of numerous biomolecules and complexes.Nevertheless, cryoEM sample preparation of challenging proteins and complexes, especially those with low abundance or with preferential orientation, remains a major hurdle.We developed an